STEM CELL SCIENCE AND REGENERATIVE MEDICINES CONGRESS WORLD CONGRESS 2023 EUROPE
“Revolutionizing the way human diseases are treated”
Day 2 - Friday 10th March 2023
KEYNOTE
- Results and lessons from recent successes in clinical development
- Science, ethics and communication contribute to success of cell-based therapies
CELL MANIPULATION PLATFORM
- Innovative tools and technology for analysis of single cells and cell-cell interaction
- Microfluidic particle manipulation using high frequency surface acoustic waves
- Gene editing and manipulation using CRISPR/Cas9 technology
REGENERATIVE MEDICINE MODELS AND TECHNOLOGIES
- Evaluation of chick embryo cryoinjury model for the study of embryonic organ development and repair
- Artificial thymus in recreating microenvironmental cues to direct T Cell differentiation and thymic regeneration
- Computational modeling of muscle regeneration and adaptation to advance muscle tissue regeneration strategies
- Contribution of dermal-derived mesenchymal cells during liver repair in two different experimental models
- Gingival fibroblasts as autologous feeders for induced pluripotent stem cells
- Direct cardiac cellular reprogramming for cardiac regeneration
- Bone regeneration using freshly isolated autologous stromal vascular fraction of adipose tissue in combination with calcium phosphate ceramics
- Tumor-free transplantation of patient-derived induced pluripotent stem cell progeny for customized islet regeneration
Cecilia Götherström, Research group leader, Associate Professor in Stem Cell Science, Karolinska Institutet
CASE STUDY
- Contribution of complex systems to entrepreneurship
- Literature review and proposed guidelines for social entrepreneurship and cross-sector collaborations
- Clinical development and commercialization of one-time potentially curative therapies
STEM CELL AND TISSUE ENGINEERING APPLICATIONS
- Mesenchymal stem cells can be recruited to wounded tissue via hepatocyte growth factor‐loaded biomaterials
- Co-culture-expanded human basal epithelial stem cells for application in tracheal tissue engineering
- Adipose-derived stem cell differentiation as a basic tool for vascularized adipose tissue engineering
- Selective differentiation into hematopoietic and cardiac cells from pluripotent stem cells based on the expression of cell surface markers
- PRC2 component JARID2 for critical maintenance of leukemic stem cells
- Targeting PTPRK-RSPO3 colon tumours for differentiation and loss of stem-cell function
REGULATORY, ETHICAL AND QUALITY CONSIDERATIONS
16:00 - REGULATORY STATUS AND PERSPECTIVE IN REGENERATIVE MEDICINE: FROM CLINICAL TRIAL TO MARKETING
- Regulatory aspects of pre-clinical studies for regenerative medicine
- Recent policies that support clinical application of induced pluripotent stem cell-based regenerative therapies
- The future for regulation and reimbursement in bringing regenerative medicines to the clinic
- Clinical landscape and manufacturing challenges in regenerative medicine
- Specific GMP legislation for quality requirements in tissue engineering
- Quality assurance in bio-banking for pre-clinical research
- Use of organ chips for quality assurance in regenerative medicine
PANEL DISCUSSION
- Convergence of regenerative medicine and synthetic biology to develop standardized and validated models of human diseases with clinical relevance
- Possible trends in product safety and standardization of manufacturing regenerative products
- How to address ethical pluripotent stem cells in the United Kingdom and Japan