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  • Stem Cell day 2

STEM CELL SCIENCE AND REGENERATIVE MEDICINES CONGRESS WORLD CONGRESS 2022 EUROPE

“Revolutionizing the way human diseases are treated”

Day 2 - Friday 7th October 2022

KEYNOTE 

  • Results and lessons from recent successes in clinical development
  • Science, ethics and communication contribute to success of cell-based therapies

CELL MANIPULATION PLATFORM

  • Innovative tools and technology for analysis of single cells and cell-cell interaction
  • Microfluidic particle manipulation using high frequency surface acoustic waves
  • Gene editing and manipulation using CRISPR/Cas9 technology

REGENERATIVE MEDICINE MODELS AND TECHNOLOGIES

  • Evaluation of chick embryo cryoinjury model for the study of embryonic organ development and repair
  • Artificial thymus in recreating microenvironmental cues to direct T Cell differentiation and thymic regeneration
  • Computational modeling of muscle regeneration and adaptation to advance muscle tissue regeneration strategies
  • Contribution of dermal-derived mesenchymal cells during liver repair in two different experimental models
  • Gingival fibroblasts as autologous feeders for induced pluripotent stem cells
  • Direct cardiac cellular reprogramming for cardiac regeneration
  • Bone regeneration using freshly isolated autologous stromal vascular fraction of adipose tissue in combination with calcium phosphate ceramics
  • Tumor-free transplantation of patient-derived induced pluripotent stem cell progeny for customized islet regeneration

CASE STUDY

  • Contribution of complex systems to entrepreneurship
  • Literature review and proposed guidelines for social entrepreneurship and cross-sector collaborations
  • Clinical development and commercialization of one-time potentially curative therapies

STEM CELL AND TISSUE ENGINEERING APPLICATIONS

  • Mesenchymal stem cells can be recruited to wounded tissue via hepatocyte growth factor‐loaded biomaterials
  • Co-culture-expanded human basal epithelial stem cells for application in tracheal tissue engineering
  • Adipose-derived stem cell differentiation as a basic tool for vascularized adipose tissue engineering
  • Selective differentiation into hematopoietic and cardiac cells from pluripotent stem cells based on the expression of cell surface markers
  • PRC2 component JARID2 for critical maintenance of leukemic stem cells
  • Targeting PTPRK-RSPO3 colon tumours for differentiation and loss of stem-cell function

REGULATORY, ETHICAL AND QUALITY CONSIDERATIONS

  • Regulatory aspects of pre-clinical studies for regenerative medicine
  • Recent policies that support clinical application of induced pluripotent stem cell-based regenerative therapies
  • The future for regulation and reimbursement in bringing regenerative medicines to the clinic
  • Clinical landscape and manufacturing challenges in regenerative medicine
  • Specific GMP legislation for quality requirements in tissue engineering
  • Quality assurance in bio-banking for pre-clinical research
  • Use of organ chips for quality assurance in regenerative medicine

PANEL DISCUSSION 

  • Convergence of regenerative medicine and synthetic biology to develop standardized and validated models of human diseases with clinical relevance
  • Possible trends in product safety and standardization of manufacturing regenerative products
  • How to address ethical pluripotent stem cells in the United Kingdom and Japan
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