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STEM CELL SCIENCE AND REGENERATIVE MEDICINES WORLD CONGRESS 2022

“Revolutionizing the way human diseases are treated”

Holiday Inn London - Bloomsbury, an IHG Hotel, LONDON, UK

6th - 7th October 2022

INTRODUCTION

Stem cell research, tissue engineering, and regenerative medicine hold the potential to revolutionize the way human diseases are treated, and many nations have therefore invested heavily in these genetically engineered components and its applications. Considerable research has enabled the fabrication of sophisticated grafts and cell manipulation technologies to analyze the molecular level of controlling cell behavior and repairing tissue. However, these revolutionary medicines are also controversial with many ethical and regulatory questions that impact a nation’s policies.

The upcoming 2022 Stem Cell Science and Regenerative Medicines Congress focuses on a diverse range of topics and addresses the challenges, obstacles, and opportunities for innovation in the design and execution of clinical trials.

This will also offer and provide a unique platform for knowledge sharing and convergence from Pharmaceuticals, Biotechnology, Regulatory, and many more.

Gain insights on:

  • Trends in stem cell-based disease modelling and drug discovery
  • Challenges, solutions, and progress on cell manufacturing and standardization
  • The clinical and regulatory landscape of regenerative products
  • Commercializing stem cell therapy and regenerative medicine and the importance of collaboration
  • Ethical, legal, and social issues in regenerative medicine
  • Driving productivity and economic growth in advanced therapies
  • Current and Future approaches to GMP manufacturing and Standardization
  • Scalable production of Human Induced Pluripotent Stem Cells
  • Cell manipulation platform
  • Regenerative Medicines Models and Technologies
  • Stem Cell and Tissue Engineering Applications

Who will you meet? 

Network with scientists, analysts, senior VPs, Heads, Directors, and Managers of leading biopharmaceutical, biotech companies, Governments agencies, and Academia, whose responsibilities includes:

  • Pre-clinical and clinical trials of stem cell therapy
  • Stem Cell Manufacturing
  • Stem Cell Therapy
  • Stem cell reprogramming
  • Regulatory policies
  • Molecular Stem Cell Biology
  • Developmental Biology
  • Stem Cell-Based Assay Development
  • Translational Medicine
  • Stem Cell Biology
  • Regenerative Medicine
  • Tissue and Cell Engineering
  • Day 1 - 27th June 2022
  • Day 2 - 28th June 2022

STEM CELL SCIENCE AND REGENERATIVE MEDICINES CONGRESS WORLD CONGRESS 2022 EUROPE

“Revolutionizing the way human diseases are treated”

Day 1 - Thursday 6th October 2022

  • Recent policies that support clinical application of induced pluripotent stem cell-based regenerative therapies
  • How different markets approach the regulation and commercialization of advanced therapies
  • Current data on how product effects clinical outcomes

PRODUCT, PROCESS AND MANUFACTURING DEVELOPMENT

  • Implications and advances in stem cell therapy (T-Cells, NK Cells, DCs, Vaccines, iPSCs & MSCs)
  • Setting global standards for stem cell research and clinical translation
  • Use of chip-based microsystems for genomic and proteomic analysis
  • Developing nanostructured thin films as biomimetic tissue-engineered platform for cancer research
  • Applications of high-throughput cellular microarray platforms in drug discovery, toxicology and stem cell research
  • Generation of human pluripotent stem cell-derived hepatocyte-like cells for drug toxicity screening
  • Using mouse and human pancreatic organoids to infer resistance to targeted therapy
  • Patient-derived organoids as an in vitro model of neuroendocrine tumors
  • Brain-region-specific organoids using mini-bioreactors for modeling ZIKV exposure
  • Regulation of ribosome biogenesis and protein synthesis controls germline stem cell differentiation
  • Global regulatory developments for clinical stem cell research
  • Issues surrounding the authentication and quality of induced pluripotent stem cells

STEM CELL PRODUCT, PROCESS AND MANUFACTURING DEVELOPMENT

  • Flow-induced epigenetic mechanisms of endothelial gene expression
  • Emerging role of nutri-epigenetics in inflammation and cancer
  • Epigenomic annotation of regulatory changes in adult tissue and stem cell based models
  • Advancing biomaterials of human origin for tissue engineering
  • Bio-inspired 3D microenvironments for stem cell reprogramming
  • Implementing oxygen control in chip-based cell and tissue culture systems

Process parameters for the high-scale production alginate-encapsulated stem cells for storage and distribution throughout the cell therapy supply chain

CASE STUDY

  • Computational tools for stem cell biology
  • Developing an automated robotic factory for novel stem cell therapy production
  • Issues of supplying new technologies into highly regulated markets

PANEL DISCUSSION 

  • Innovative, comprehensive mapping and multiscale analysis of registered trials for stem cell-based regenerative medicine
  • Failure mode and effects analysis to reduce risks of errors in the good manufacturing practice production of engineered tissue and cells
  • Regulatory requirements in the good manufacturing practice production of an epithelial cell graft for ocular surface reconstruction

STEM CELL SCIENCE AND REGENERATIVE MEDICINES CONGRESS WORLD CONGRESS 2022 EUROPE

“Revolutionizing the way human diseases are treated”

Day 2 - Friday 7th October 2022

KEYNOTE 

  • Results and lessons from recent successes in clinical development
  • Science, ethics and communication contribute to success of cell-based therapies

CELL MANIPULATION PLATFORM

  • Innovative tools and technology for analysis of single cells and cell-cell interaction
  • Microfluidic particle manipulation using high frequency surface acoustic waves
  • Gene editing and manipulation using CRISPR/Cas9 technology

REGENERATIVE MEDICINE MODELS AND TECHNOLOGIES

  • Evaluation of chick embryo cryoinjury model for the study of embryonic organ development and repair
  • Artificial thymus in recreating microenvironmental cues to direct T Cell differentiation and thymic regeneration
  • Computational modeling of muscle regeneration and adaptation to advance muscle tissue regeneration strategies
  • Contribution of dermal-derived mesenchymal cells during liver repair in two different experimental models
  • Gingival fibroblasts as autologous feeders for induced pluripotent stem cells
  • Direct cardiac cellular reprogramming for cardiac regeneration
  • Bone regeneration using freshly isolated autologous stromal vascular fraction of adipose tissue in combination with calcium phosphate ceramics
  • Tumor-free transplantation of patient-derived induced pluripotent stem cell progeny for customized islet regeneration

CASE STUDY

  • Contribution of complex systems to entrepreneurship
  • Literature review and proposed guidelines for social entrepreneurship and cross-sector collaborations
  • Clinical development and commercialization of one-time potentially curative therapies

STEM CELL AND TISSUE ENGINEERING APPLICATIONS

  • Mesenchymal stem cells can be recruited to wounded tissue via hepatocyte growth factor‐loaded biomaterials
  • Co-culture-expanded human basal epithelial stem cells for application in tracheal tissue engineering
  • Adipose-derived stem cell differentiation as a basic tool for vascularized adipose tissue engineering
  • Selective differentiation into hematopoietic and cardiac cells from pluripotent stem cells based on the expression of cell surface markers
  • PRC2 component JARID2 for critical maintenance of leukemic stem cells
  • Targeting PTPRK-RSPO3 colon tumours for differentiation and loss of stem-cell function

REGULATORY, ETHICAL AND QUALITY CONSIDERATIONS

  • Regulatory aspects of pre-clinical studies for regenerative medicine
  • Recent policies that support clinical application of induced pluripotent stem cell-based regenerative therapies
  • The future for regulation and reimbursement in bringing regenerative medicines to the clinic
  • Clinical landscape and manufacturing challenges in regenerative medicine
  • Specific GMP legislation for quality requirements in tissue engineering
  • Quality assurance in bio-banking for pre-clinical research
  • Use of organ chips for quality assurance in regenerative medicine

PANEL DISCUSSION 

  • Convergence of regenerative medicine and synthetic biology to develop standardized and validated models of human diseases with clinical relevance
  • Possible trends in product safety and standardization of manufacturing regenerative products
  • How to address ethical pluripotent stem cells in the United Kingdom and Japan
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